ABSTRACT
Following improvements in therapy for childhood malignancies, the striking increase in survival rate over the past 30 years has led to the increase risk of developing second malignant neoplasms (SMNs). We report a case of colorectal carcinoma as a SMN, following treatment for rhabdomyosarcoma. The patient was diagnosed with rhabdomyosarcoma of the urinary bladder at his age of three years, and developed adenocarcinoma in the colon 13 years later. Histologic examination of the surgical specimen revealed adenocarcinoma involving the rectosigmoid area with radiation colitis in its background. The tumor cells showed strong immunoreactivity for p53 protein, suggesting the role of irradiation and p53 mutation in carcinogenesis. This case emphasizes the need for dose observation in survivors of early childhood malignancies treated with radiation and multiagent chemotherapy.
Subject(s)
Humans , Male , Adenocarcinoma/pathology , Adenocarcinoma/genetics , Adenocarcinoma , Adolescent , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Antineoplastic Combined Chemotherapy Protocols , /radiotherapy , /drug therapy , Colitis/pathology , Colitis/etiology , Colorectal Neoplasms/pathology , Colorectal Neoplasms/genetics , Colorectal Neoplasms , Combined Modality Therapy , Cyclophosphamide/adverse effects , Cyclophosphamide , Doxorubicin/adverse effects , Doxorubicin , Genes, p53 , Neoplasm Proteins/analysis , Neoplasms, Radiation-Induced/pathology , Neoplasms, Radiation-Induced/genetics , Neoplasms, Radiation-Induced , Neoplasms, Second Primary , Tumor Suppressor Protein p53/analysis , Radiation Injuries/pathology , Radiation Injuries/etiology , Radiotherapy , /radiotherapy , /drug therapy , Sigmoid Neoplasms/pathology , Sigmoid Neoplasms/genetics , Sigmoid Neoplasms/etiology , Time Factors , Vincristine/adverse effects , VincristineABSTRACT
Following improvements in therapy for childhood malignancies, the striking increase in survival rate over the past 30 years has led to the increase risk of developing second malignant neoplasms (SMNs). We report a case of colorectal carcinoma as a SMN, following treatment for rhabdomyosarcoma. The patient was diagnosed with rhabdomyosarcoma of the urinary bladder at his age of three years, and developed adenocarcinoma in the colon 13 years later. Histologic examination of the surgical specimen revealed adenocarcinoma involving the rectosigmoid area with radiation colitis in its background. The tumor cells showed strong immunoreactivity for p53 protein, suggesting the role of irradiation and p53 mutation in carcinogenesis. This case emphasizes the need for dose observation in survivors of early childhood malignancies treated with radiation and multiagent chemotherapy.